The adrenal glands may be lacking in the body, or be present excessively. Both cases are a risk.
Metabolism in general can be divided conceptually into many parts but is usually done in 2 mainly is anabolism and catabolism. When there is an abnormal metabolism it is when you consider that there is a disease.
Osteoporosis is generally asymptomatic until the fracture is present. Treatment consists of changes in lifestyle and use of medications.